Washington • Exercise may do more than keep a healthy brain fit: New research suggests working up a good sweat may also offer some help once memory starts to slide— and even improve life for people with Alzheimer's.

The effects were modest, but a series of studies reported Thursday found vigorous workouts by people with mild memory impairment decreased levels of a warped protein linked to risk of later Alzheimer's — and improved quality of life for people who already were in early stages of the disease.

"Regular aerobic exercise could be a fountain of youth for the brain," said cognitive neuroscientist Laura Baker of Wake Forest School of Medicine in North Carolina, who reported some of the research at the Alzheimer's Association International Conference. Exercise is good for the heart, which in turn is good for the brain. Research shows physical activity can improve cognition in healthy older people, potentially lowering their risk of developing dementia.

With no medications yet available to slow Alzheimer's creeping brain destruction, the new findings point to lifestyle changes that might make a difference after memory impairment begins as well.

"It's important for caregivers especially to think how to keep loved ones as engaged as possible. The last thing they should do is keep their loved one at home watching TV," said Alzheimer's Association chief science officer Maria Carrillo.

How much exercise? In studies from North Carolina, Denmark and Canada, people got 45 minutes to an hour of aerobic exercise three or four times a week.

Baker's research is getting particular attention because it's one of the first to find exercise can affect tau, an Alzheimer's hallmark that causes tangles in brain cells.

Baker studied 71 previously sedentary older adults who have hard-to-spot memory changes called mild cognitive impairment that can increase risk of developing Alzheimer's.

MRI scans showed the exercisers experienced increased blood flow in brain regions important for memory and thought processing — while cognitive tests showed a corresponding improvement in their attention, planning and organizing abilities, what scientists call the brain's "executive function," Baker reported. Most intriguing, tests of spinal fluid also showed a reduction in levels of the worrisome tau protein in those over age 70.

"This is really exciting," said Dr. Laurie Ryan of the National Institute on Aging. "It's too soon to say that lowers risk" of worsening memory, she warned, saying longer studies must test if sticking with exercise makes a lasting difference.

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